Synthesis and cytotoxic activity of (2-arylquinazolin-4-yl)hydrazones of 2-hydroxybenzaldehydes
نویسندگان
چکیده
2-Phenyl-6,7-difluoro and 2-(4-fluorophenyl)quinazoline derivatives bearing salicylidenhydrazino fragments at position 4 were prepared based on 4,5-difluoroantranilic acid or anthranilamide. Molecular docking to casein kinase 2 was performed; compounds with high in silico activity CK2 revealed. Cytotoxic of the synthesized studied cancer cell line MDA-MB-231 normal WI26 VA4.
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ژورنال
عنوان ژورنال: Chimica techno acta
سال: 2023
ISSN: ['2411-1414', '2409-5613']
DOI: https://doi.org/10.15826/chimtech.2023.10.2.11